mers virus

mers virusCorona Dhexe syndrome neef- EastFrom Wikipedia oo lacag la'aan
  ( Soo gooyo bari ee neefsashada corona syndrome Dhexe)Article waxay ku saabsan tahay fayraska . Si uu cudurku , eeg neef- syndrome Middle East . Wixii dillaacay , eeg 2012 neef- syndrome Middle East corona dillaacay . Si guud oo ku saabsan fayraska , eeg Corona .MERS - makaasMERS - makaas Qurub sida aan ka arki by negative microscopy elektarooniga si tartib ah . Virions ku jira Saadaasha kooxda - sida dabeecad u wehlisa, balqanka, viral .kala-saaridda VirusGroup : Group IV ( ( + ) ssRNA )Order : NidoviralesFamily : CoronaviridaeBAHDDA : CoronavirinaeBreaking : BetacoronavirusMasaaridu : MERS - makaasThe corona Middle East syndrome neef mareenka ( MERS - makaas ) , [1] sidoo kale ku fiiqayo EMC/2012 ( HCoV-EMC/2012 ) , waa positive - dareen , RNA noocyada sheeko hal - ku xayiran of Betacoronavirus Gould .First loo yaqaan corona sheeko 2012 ama corona sheeko , waxa marka hore la sheegay in 2012 ka dib markii Iskuxigida hiddawadayaasha of fayras go'doomin saamiga xaakada ka soo bukaanada ku dhacay u jirran ee 2012 dillaacay ah ee hargabka cusub .Sida of 14 May 2014 , kiisaska MERS - makaas ayaa laga soo sheegay in dalal dhowr ah , oo ay ku jiraan Sacuudi Carabiya , Malaysia , Urdun , Qadar , Masar , Imaaraadka Carabta ee Midoobey , Tuniisiya , Kuwait , Cumaan , Filibiin , Indonesia , United Kingdom , ee Netherlands , iyo Maraykanka . [ 2 ]Tusmada
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    1 imaansho
        1.1 Origin
        1.2 Tropism
        1.3 Gudbinta
        1.4 kaydka Dabiiciga
        1.5 Taxonomy
    2 Mikrobiologi
    3 Research / IP khilaaf
    4 Corana Map
    5 Sidoo kale eeg
    6 Notes
    7 Tixraacyada
    8 links External
Imaansho [Wax ka bedel ]Fayrasku waxa uu MERS - makaas waa xubin cusub ee kooxda beta of corona ah , Betacoronavirus , genomes shumme C. MERS - makaas yihiin phylogenetically lagu tilmaamay inay laba clades , clade A iyo B. Xaaladaha horrayn of MERS ahaayeen of ay kooxahaasi clade A ( EMC / 2012 iyo Jordan-N3/2012 ) , iyo xaaladaha cusub yihiin hiddo ahaan kala duwan ( clade B ) . [ 3 ]MERS - makaas waa laga soo SARS kala duwan oo ka duwan corona ay wadaagaan - qabow oo loo yaqaan xunse aadanaha betacoronaviruses HCoV - OC43 iyo HCoV - HKU1 . [ 4 ] Ilaa 23 May 2013 , MERS - makaas lahaa si joogta ah loo gudbiyey sida fayras SARS - like , [ 5 ] ama si fudud corona ee sheeko , iyo hore u ahaa gudbiyo colloquially on messageboards sida " Saudi SARS " .Origin [Wax ka bedel ]Midkii kowaad wuxuu u xaqiijiyey Xaaladaha ayaa la soo sheegay in isbitaalka in Amman , Urdun , ka mida shaqaalaha daryeelka caafimaadka iyo shaqaalaha kalkaalinta ee April 2012 , halkaas oo xaalado ah ayaa la ogaado inay isugu gudbiyo H2H . Later 60 -sano jir ah qof bukaan ah oo lab ah ula oof- xumada ba'an iyo kelyaha ba'an , ayaa ku dhintay Jeddah , Saudi Arabia , on 24 June 2012 . [ 4 ] virologist Masaarida Dr Ali Mohamed Zaki go'doonsan iyo aqoonsaday corona hore aan la garanayn ninka ee sambabada . [ 6 ] [ 7 ] [ 8 ] Dr Zaki kadibna posted natiijada uu on 24 September 2012 on SOHTA -mail . [ 7 ] [ 9 ] [ 9 ] unugyada go'doon muujiyeen saamaynta cytopathic ( CPE ) , foomka of Dafiray in iyo dhisidda syncytia . [ 9 ]Kiis labaad laga helay September 2012 . A 49 -year- old oo lab ah oo ku nool Qadar lagu soo bandhigay astaamaha hargabka la mid ah , oo isku xigxiga oo fayruska ahayd ku dhowaad isku mid ah in kiiska ugu horeeya . [ 4 ] In November 2012 , kiisaska la mid ah u muuqday ee Qadar iyo Saudi Arabia . Xaaladaha dheeraad ah ayaa xusay , oo ay dhimashada la xiriira , iyo cilmi- deg-dega ah iyo la socodka this corona sheeko bilaabay .Lama hubo in caabuqa ay yihiin natiijada dhacdo keliya oo arintaasi la leh aadanaha -ka- insaanka ku xiga isu gudbinta , ama haddii goobaha juqraafiyeed kala duwan ee cudurka wakiil dhacdooyinka arintaasi kala duwan ka soo isha caadi ah aan la garanayn .Daraasad by aragax Memish ee Riyadh University iyo asxaabta soo jeedisay in fayruska mararka qaar ka kacay inta u dhaxaysa July 2007 iyo June 2012 , kula laga yaabaa in sida ugu badan 7 kala arintaasi gooni ah . Waxaa ka mid berkadood xayawaanka , makaas leeyahay kala duwanaanshaha hidde ballaaran oo weli qofka shaybaarka laga soo bilaabo bukaannada soo jeedin hiddawadayaasha la mid ah , sidaa daraaddeedna ay caadi , inkastoo xogta waa kooban . Waxaa la go'aamiyey iyada oo loo marayo falanqayn saacad kelli , in fayrusyada oo ka EMC/2012 iyo taariikhda England/Qatar/2012 in ay goor hore 2011 doodayno in xaaladahan ka mid ahi ka degay dhacdo keliya oo arintaasi . Waxay ka muuqan lahayd ee - MERS , makaas ayaa ku wareegaya dadyowga bini'aadanka ah ee ka weyn yahay hal sano ah iyada oo aan la ogaado iyo jeedinaysaa transmission ka madax bannaan isha la aqoon . [ 10 ] [ 11 ]Tropism [Wax ka bedel ]In aadanuhu , fayraska leeyahay tropism xooggan ee unugyada xiiqlayn bronki nonciliated , iyo waxaa la muujiyay in ay si wax ku ool ka dhuunto jawaabaha difaaca la dhalin iyo wax soo saarka antagonizeinterferon ( dartid ) ee unugyadan . Tropism Tani waa mid gaar ah oo ku tahay in fayrusyada ugu -mareenka abaaro unugyada ciliated . [ 12 ] [ 13 ]Maaddaama ay isku mid bukaan-eegtada u dhexeeya MERS - makaas iyo SARS - makaas , waxaa la soo jeediyey in ay isticmaali karaan receptor isla uurkuna ; exopeptidase ah , angiotensin Insaymkaas ay Masiixiyiin 2 ( ACE2 ) [ 14 ] Si kastaba ha ahaatee , waxaa markii dambe la helay neutralization in of ACE2 by antibodies recombinant aanu reebayn xanuunka MERS - makaas [ 15 ] cilmi baaris dheeraad ah peptidase dipeptyl aqoonsaday 4 ( DPP4 ; . . sidoo kale loo yaqaan CD26 ) sida a receptor uurkuna functional for MERS - makaas . [ 13 ] ka duwan dhaweeyayaasha kale corona la garanayo , waxqabad enzymatic of DPP4 ah looma baahna infekshanka . Sida la filayo in ay , ku saleynayo amino acid of DPP4 ah aqoon u leh waa conserved oo dhan noocyada iyo waxa lagu tilmaamay epithelium aadanaha bronki iyo kelyaha . [ 13 ] [ 16 ] hiddo- Bat DPP4 u muuqan in lagu maado si Heer sare ah ee horumar xadaddka sida a jawaab u ah infekshannada ku corona , sidaas tafiirtii keentay in MERS - makaas ayaa laga siidaayey laga yaabaa in dadka fiidmeerta muddo dheer ka hor intaan lagu kala qaado dadka . [ 17 ]Gudbinta [Wax ka bedel ]On 13 February 2013 , Ururka Caafimaadka Adduunka ayaa sheegay " halista isu gudbinta dabadheeraatay qof -ka- qof muuqataa in ay tahay mid aad u yar . " [ 18 ] Unugyada MERS - makaas qaadsiiyo ee sanbabada , Xisaabiye oo kaliya 20 % ka mid ah unugyada xiiqlayn -mareenka , sidaas tiro badan oo ah virions yihiin laga yaabo in loo baahan yahay in hoos loo nuugo in uu cudur . [ 16 ]Sida of 29 May 2013 , WHO hadda in fayruska MERS - makaas waa " hanjabaad in ay dunida oo dhan . " [ 19 ] Si kastaba ha ahaatee , Dr Anthony S. Fauci ee Machadyada Caafimaadka ee yidhaahda Beytesda oo , Maryland , ayaa sheegay in sida ee hadda MERS - makaas " ma faafin qof oo joogto ah si hab qofka at dhan . " Dr Fauci sheegay in ay jirto khatar ka iman kara in in waxa suurtogal ah in fayraska la joogaba galay cadaadis ah in aanu baahin qof ilaa ka qof . [ 20 ]Infeekshanka waxaa shaqaalaha daryeelka caafimaadka ( HCW ) keenaysaa in walaac of aadanaha si ay isugu gudbiyo aadanaha . [ 21 ]The Centers for Xakamaynta iyo Kahortagga Cudurrada (CDC) Liiska MERS sida laysku qaadsiyo ka soo aadanaha -ka- insaanka . From ay FAQ , in jawaabta su'aasha ah " MERS - makaas faafinta qof ilaa ka qof ?" , Iyana waxay ugu jawaabi " MERS - makaas ayaa la sheegay inay ku fidi u dhexeeya dadka ku jira dhow Gudbinta xiriir . Ka yimi bukaanjiifka oo qaba cudurka shaqaalaha daryeelka caafimaadka uu leeyahay sidoo kale waxa la arkay . Kooxaha ka mid ah xaaladaha dalal badan oo waa la baarayaa . " . [ 22 ] Waxaa jira sidoo kale waa article New York Times ah oo siiya caanka ah correlative for this . [ 23 ]Kaydka Dabiiciga ah [Wax ka bedel ]Cilmi baaris Hore jeediyey fayraska la xiriira mid ka mid helay in fiidmeerta xabaashii Masaarida . Bishii September 2012 Ron Fouchier Cobtic- fayraska laga yaabaa asalkiisu ka soo jeedo ee Fiidmeerta . [ 24 ] shaqee by epidemiologist Ian Lipkin of University Columbia ee New York ayaa muujisay in fayruska go'doomin fiidmeerta a eegay inuu noqdo ciyaar si fayraska laga helay aadanuhu . [ 25 ] [26] [27] betacoronaviruses 2C ah ayaa la ogaado in Fiidmeerta Nycteris in Fiidmeerta Ghana iyo Pipistrellus Yurub in ay yihiin phylogenetically la xiriira ka virus MERS - makaas . [ 28 ]Shaqada Recent xiraysaa oo geel ah in ay fayruska . Ka hor - of - daabacaad ugu yeertay ah wargeys ka Soo Shaacbaxaya Infectious Diseases diiwaanka cilmi- muujinaya cudurka corona in weylood , iyaday geela iyo dadka waaweyn , 99.9 % ku habboon si ay genomes of clade aadanaha B MERS - makaas ay . [ 29 ]Ugu yaraan hal qof , kuwaas oo ay hoos u dhacday jiran leh MERS yaqaanay in ay u soo galeen xiriir la geel ama dhawaan cabbeen caanaha geela . [ 30 ]On 9 August 2013 , warbixin ah ee Macalester The Cudurada Lancet Infectious muujisay in 50 out of 50 ( 100 % ) serum dhiig ka soo geel Cumaan iyo 15 of 105 (14%) laga bilaabo geel Isbaanish lahaa antibodies protein - gaar ah ka gees ah ku - MERS , makaas gooyay borotiin . Serum Dhiig ka yimaada ido Yurub , riyaha , lo'da , iyo digo oo kale ma uu lahayn feyruska . [31] Dalalka sida Sacuudi Carabiya iyo Imaaraadka Carabta ee Midoobey soo saaro iyo ku baabbi'iyee xaddi badan oo hilibka geela. Suurtagalnimada waxay ka jirtaa in Fiidmeerta Afrika ama Australian qabno fayraska iyo waxa gudbiyaan si geel . Geel laga keeno gobolladan ayaa laga yaabaa in fiiruska Bariga Dhexe . [ 32 ]In 2013 MERS - makaas la xaqiijiyey in saddex xubnood oo lo ' ah , iyaday geela ayaa lagu qabtay barn Qadar a , oo la xidhiidhay in ay laba xaaladood aadanaha ayaa xaqiijiyay haysta tan iyo kabsaday . Joogitaanka MERS - makaas in geelii la xaqiijinin by Machadka Qaranka ee Caafimaadka Dadweynaha iyo Deegaanka ( RIVM ) ee Wasaaradda Caafimaadka iyo Caafimaadka Erasmus Center ( WHO iskaashi Center ) , Holland . None of geel ay muujiyeen calaamad kasta oo Cudurka markii tijaabada la geeyay loo ururin jiray . Golaha Sare ee Qadar ee Caafimaadka talinayaa in November 2013 in dadka qaba xaaladaha caafimaad , sida cudurrada wadnaha , macaanka , kelyo xanuun , cudur -mareenka , difaacooda , iyo dadka waayeelka ah , iska ilaali wixii xiriir xayawaanka dhow marka beeraha iyo suuqyada booqanaya , iyo in ay tababarato nadaafadda wanaagsan , sida gacmaha lagu dhaqo . [ 33 ]A waxbarasho dheeraad ah ayaa geelii , iyaday ka soo Sacuudi Carabiya oo lagu daabacay December 2013 muujiyey joogitaanka MERS - makaas in 90 % oo ka mid ah geel qiimeeyo , iyaday ( 310 ) , taasoo tilmaamaysa in geel iyo rakuubbo ma aha oo kaliya uu noqon karaa kaydka weyn ee MERS - makaas , laakiin sidoo kale source xayawaanka ee MERS . [ 34 ]Sida laga soo xigtay 27 March 2014 MERS - makaas update oo kooban , baaritaano dhawaan la taageero in geel u adeegaan sida isha asaasiga ah ee ku MERS - makaas aadanuhu ku daartaan , halka Fiidmeerta waxaa laga yaabaa in kaydka dambaysta ah ee fayraska . Caddayn waxaa ka mid ah inta jeer ee ay la taasoo fayraska ayaa laga helay oo geel ah , kuwaasi oo xaalado aadanaha ayaa lagu soo bandhigo , xogta seriological taas oo muujinaysa isugu gudbiyo baahsan ee geel , iyo isku mid ah oo makaas geela si makaas aadanaha . [35]Taxonomy [Wax ka bedel ]MERS - makaas waxaa la more si dhow ula xiriira coronaviruses fiidmeerta HKU4 iyo HKU5 ( 2C shumme ) ka badan waa in ay SARS - makaas ( 2B shumme ) ( 2 , 9 ) , aqoonsiga saleynayo in ka badan 90 % xidhiidhka ugu dhow la wadaago , fiidmeerta coronaviruses HKU4 iyo HKU5 sidaas darteed loo arkaa in ay ka tirsan yihiin isla noocyada by Guddiga Caalamiga on Taxonomy of Fayrus ( ICTV ) .

    Mnemonic :
    Taxon aqoonsi :
    Magaca cilmiga ah : corona syndrome Bariga neef- Dhexe [1]
    Magaca Common : MERS - makaas
    Isku macno ah corona daran oo syndrome ba'an
    Magacyada kale :
        corona sheeko ( nCoV )
        Sheeko London1 , makaas 2012 [ 36 ]
        Human Corona Erasmus Medical Center/2012 ( HCoV-EMC/2012 )
    Rank :
    Max'ed :

    > Fayrus

        > Viruses ssRNA

            > Group : IV ; positive - dareen , hal - ku xayiran fayrusyada RNA

                > Order : Nidovirales

                    > Family : Coronaviridae

                        > BAHDDA : Coronavirinae

                            > Breaking : Betacoronavirus [ 37 ]

                                > Masaaridu : Betacoronavirus 1 ( si caadi ah loo yaqaan corona Human OC43 ) , Human corona HKU1 , corona Murine , Pipistrellus corona fiidmeerta HKU5 , Rousettus HKU9 corona fiidmeerta , corona daran oo syndrome la xiriira ba'an , Tylonycteris corona fiidmeerta HKU4 , MERS - makaas

    Virus ciidammada
        Aqonta ( aadanaha )
        Fiidmeerta [ 24 ] [ 25 ] [ 28 ] [ 37 ] [ 38 ]
        Doofaarka [ 37 ]
Jiidan :

    go'doomiyo :
    go'doomiyo :
    NCBI
MicrobiologFayrasku waxa uu si dhaba [ 9 ] koraa unugyada Vero iyo unugyada LLC - MK2 .Cilmi baaris / IP khilaafSaraakiisha Saudi aan la siinin ogolaansho inay Dr Zaki soo dirto muunad fayruska si Fouchier iyo waxay ku haynteeda, marka Fouchier sheegtay patent ku saabsan taxanaha buuxa hidde [ 39 ] oo ah corona ka Middle East syndrome -mareenka . [ 39 ]Editor ee The Economist lagu arkay , " Welwel ammaanka waa in aan hakin shaqo oo degdeg ah . In wax laga barto virus dilaa ah waa khatar ah . Aan ka barta waa Air _ . " [ 39 ] Dr Zaki iyo Ajnabi uu shaqo ee isbitaalka sababtoo ah wadaagga isaga oo muunad iyo natiijooyinka . [ 40 ] [ 41 ] [ 42 ] [ 43 ]Mar ay shir sannadeedka of World Assembly Caafimaadka ee May 2013 , madax WHO Margaret Chan shaaca ka qaaday in hantida , ama shatiyada on fayrasyada cusub , waa in la daboolo quruumahaas oo lagu ilaaliyo muwaadiniinta ay by xadidaysa Cilmibaaris . Wasiir ku xigeenka Caafimaadka iyo aragax Memish abuurtay walaac in yahannada qabtay patent for the virus MERS - makaas uma uu oggolaan in aqoonyahaniinta kale si ay u isticmaalaan wax tiga iyo ahaayeen Sidaa darteed daahiyaan horumarinta baaritaanka lagu ogaanayo . [ 44 ] Erasmus MC ku jawaabay in ay codsiga patent ma yeeleen xaddido cilmi-baarista caafimaadka dadweynaha galay corona MERS , [ 45 ] iyo in fayraska iyo baaritaan lagu ogaanayo la geeyey - oo lacag la'aan ah - si codsadey reagents sida oo dhan .