mers huaketo

mers huaketo Kura Te Tai Rāwhiti coronavirus syndrome romahā Mai i Wikipedia, te mātāpunenga free
  (Tukuna i Reanga matehā rawhiti coronavirus syndrome) Tēnei tuhinga, ko e pā ana ki te huaketo. Hoki i te mate, kia kite Middle Te Tai Rāwhiti romahā syndrome. Hoki i te pakarutanga, kite 2012 Middle Te Tai Rāwhiti romahā syndrome coronavirus pakarutanga. Hoki whānui e pā ana ki te huaketo, kite Coronavirus. MERS-ngaahi Matūriki MERS-ngaahi rite kite i te kino microscopy poke irahiko. Virions ngā haurangi karapu-rite āhuatanga e ahu i te membrane viral. Classification huaketo Group: IV Group (() ssRNA +) Order: Nidovirales Family: Coronaviridae Iti: Coronavirinae Puninga: Betacoronavirus Momo: MERS-ngaahi Ko te Middle Te Tai Rāwhiti coronavirus syndrome romahā (MERS-ngaahi), [1] kiia hoki EMC/2012 (HCoV-EMC/2012), ko te tikanga-pai, kotahi-paea riihitia ana ngā momo pūrākau o te puninga Betacoronavirus. Ka karanga tuatahi coronavirus pūrākau 2012 noa coronavirus pukapuka ranei, i korerotia i roto i te reira i te tuatahi i muri i te tau 2012 genome whakaraupapa o te huaketo i herea ki tauira sputum i tūroro i hinga mate i roto i te pakarutanga o te rewharewha 2012 hou. I o te 14 o Mei 2014, kua korerotia take MERS-ngaahi kua i roto i nga whenua maha ngā, tae atu Hauti Arapia, Malaysia, Horano, Qatar, i Ihipa, i te United Arab Emirates, Tunisia, Kuwait, Onama, te Filipaini, Indonesia, te rangatiratanga United, te Hōrana, me te United States. [2] Contents
  [Huna]

    1 Virology
        1.1 Origin
        1.2 Tropism
        1.3 Whakawhiti
        1.4 Natural awa ki
        1.5 Taxonomy
    2 Microbiology
    3 Tautohetohe Rangahau / IP
    4 corona Mahere
    5 Titiro hoki
    6 Notes
    7 Tohutoro
    8 hononga waho
Virology [edit] Te huaketo MERS-ngaahi ko te mema hou o te rōpū beta o coronavirus, Betacoronavirus, kua phylogenetically whakarōpūtia te kawei C. MERS-ngaahi genomes ki e rua clades, clade A me B. te wā tōmua o te MERS i o clade A tautau (EMC / 2012 me te Jordan-N3/2012), me ngā take hou e motuhake ira (clade B). [3] He motuhake i te mahaha me motuhake i te coronavirus noa-matao MERS-ngaahi me betacoronaviruses mohio te tangata nei tetehi HCoV-OC43 me HCoV-HKU1 [4] Kia 23 Haratua 2013, MERS-ngaahi i pinepine i tukuna ki te rite ki te mahaha-rite. , [5] ranei noa te coronavirus pukapuka, me wawe i tukua e ia ki te colloquially i runga i messageboards rite te "Hauti te mahaha". Origin [edit] Whakapumautia te tuatahi pūrongo kēhi i roto i te hōhipera i Amman, Horano, i roto i nga kaimahi tiaki hauora me te kaimahi i te u, i roto i te April 2012, i te wahi i takoto te take ki te tuku H2H kia. I muri mai ka mate a manawanui tane-tau 60-tawhito ki te kakā whakapeka me te mate täkihi te piwa, i roto i Jeddah, Hauti Arapia, i te 24 o Pipiri 2012. [4] tawhiti virologist Ihipiana Dr Ali Mohamed Zaki ka kitea e te coronavirus mua unknown i pūkahukahu i te tangata o . [6] [7] [8] ka whakairi Dr Zaki tona kitenga i te 24 Mahuru 2012 i runga i ProMED-mēra. [7] [9] [9] whakakitea te ngā pūtau taratahi ngā pānga cytopathic (CPE), i roto i te puka o Māmā me te hanganga syncytia. [9] Kitea te take tuarua i roto i te marama o Mahuru 2012. He tane-tau 49-tawhito e noho ana i roto i Qatar aroaro tohu rewharewha rite, a ko tata ōrite ki taua o te take tuatahi he raupapa o te huaketo. [4] I te Noema 2012, ka puta ngā take ōrite i roto i te Qatar a Hauti Arapia. I kitea atu take, ki te mate e hāngai ana, me te rangahau, me te aroturuki tere o tenei coronavirus pūrākau ka tīmata. Ehara i te mea tetahi, ahakoa i te mate, ko te hua o te hui zoonotic kotahi ki muri tuku tangata-ki-te tangata, ki te te wāhi matawhenua maha o te mate tohu ngā zoonotic maha i te puna unknown noa ranei. He ako i Ziad Memish o University Riyadh me hoa kōrero e whakatika te wā i te huaketo i waenganui i Hōngongoi 2007, me te Pipiri 2012, ki te pea te hunga i rite 7 ngā reo motuhake zoonotic. I roto i Faarii kararehe, kua ngaahi he kanorau nui iranga ano te tauira i ngā tūroro fokotuu atu he genome rite, a reira puna noa, ahakoa he iti te raraunga. Kua takoto i roto i te tātari karaka rāpoi, e ngā wheori i te EMC/2012 me England/Qatar/2012 rā ki te tīmatanga o 2011 fokotuu e heke kei enei take i te hui zoonotic kotahi. Puta e te reira i te MERS-ngaahi kua komuhumuhu i roto i te iwi, kua tangata hoki nui atu i te kotahi tau, kahore he rapunga a kōrero tuku motuhake i te puna unknown. [10] [11] Tropism [edit] I roto i te tangata, he te huaketo i te kaha tropism mo nonciliated ngā pūtau epithelial arahau, a kua whakaaturia ki te kōhetehete, tōtika te whakautu ārai kowhatu me antagonizeinterferon (IFN) hua i roto i enei ngā pūtau. Ko te ahurei tenei tropism i hāngai e ngā wheori tino matehā ngā pūtau ciliated. [12] [13] Nā ki te faitatau haumanu i waenganui MERS-ngaahi me te mahaha-ngaahi, i whakaaro te reira e kia whakamahi ratou i te receptor pūtau taua; te exopeptidase, angiotensin paru tahuri 2 (ACE2) [14] Heoi, i muri mai ka kitea te reira e kore e taua neutralization o ACE2 i he paturopi recombinant ārai MERS-ngaahi mate [15] rangahau anō dipeptyl i tautuhia peptidase 4 (DPP4:.. ano hoki e mohiotia ana ko CD26) rite te receptor pūtau mahi hoki MERS-ngaahi. [13] Tērā anō ētahi atu receptors coronavirus mohio, e kore te mahi enzymatic o DPP4 te hiahiatia mō te mate. I te e tūmanakohia ana, kei te te raupapa waikawa amino o DPP4 tino oranga puta noa i ngā momo, me te whakahuatia i roto i te epithelium arahau tangata, me nga whatukuhu. [13] [16] puta te tamahine DPP4 ira ki kua kaupapa ki te nui rawa o te whanaketanga urutau rite ki te urupare ki te mate coronavirus, na te kāwai ārahi ki MERS-ngaahi pea ka huri haere i roto i te taupori pekapeka hoki o te wā, he wā roa i mua i te tuku ki te iwi. [17] Tuku [edit] I te 13 o Hui-tanguru 2013, i kī te Health Organization World "puta te mōrea o te tuku toitü tangata-ki-tangata ki te e tino iti." [18] Ko te pūtau i pāngia e MERS-ngaahi i roto i te pūkahukahu pūkete anake hoki 20% o ngā pūtau matehā epithelial, na kei te hiahiatia pea he maha nui o virions ki te e inhaled ki te meinga te mate. [16] I o 29 Mei 2013, i te kei te whakatupato WHO inaianei e te huaketo MERS-ngaahi ko te "tuma ki te ao katoa." [19] Heoi, Dr Anthony S. Fauci o te National Pütahi Health i Petehera, Maryland, kī e rite o MERS-ngaahi Na "e kore e horahia e i roto i te tangata ōrite te ki te tangata te ara i katoa." Dr Fauci kī e he tata pea i roto i taua he e taea hoki ki te huaketo mutate ki Atira e e tuku i te tangata ki te tangata. [20] Ko te mate o te kaimahi hauora (HCW) arata'i ki āwangawanga o te tangata ki te tuku tangata. [21] Ko te Senitā mo mate Control me te Ārai (CDC) MERS rārangi rite pērā i te tangata-ki-te tangata. I to ratou FAQ, i roto i whakahoki ki te pātai "horapa E MERS-ngaahi i te tangata ki te tangata?", Whakahoki ratou "Kua whakaaturia MERS-ngaahi ki te whariki i waenganui i te iwi i roto i te hunga e tata whakapā. Whakawhiti i tūroro whai huaketo ki ngā kaimahi hauora kua hoki kua kitea. Kei te rangahaua tautau o ngā take i roto i nga whenua maha ngā. ". [22] He he article New York Times e whakarato ana i ētahi horopaki correlative mo tenei ano hoki. [23] Awa ki Natural [edit] Ngā rangahau e pā ana Early te huaketo ki tetahi kitea i roto i te pekapeka urupa o Ihipa. I te Mahuru 2012 speculated Ron Fouchier e ai te huaketo i ahu i roto i te pekapeka. [24] mahi i epidemiologist Ian Lipkin o University Columbia i roto i New York whakakitea e te huaketo i herea ki te pekapeka titiro ki te waiho i te kēmu ki te huaketo i kitea i roto i te tangata. [ 25] [26] [27] 2c betacoronaviruses i kitea i roto i te pekapeka Nycteris i roto i pekapeka Ghana me Pipistrellus i Europe e phylogenetically e pā ana ki te huaketo MERS-ngaahi. [28] Hononga mahi Recent kamera ki te huaketo. He pānui i mua-o-tā mo te hautaka Emerging hopuhopu Diseases records rangahau e whakaatu ana i te mate i roto i nga kuao kau coronavirus kamera kamera, me ngā pakeke, 99,9% ōrite ki te genomes o clade tangata B MERS-ngaahi [29]. I iti rawa tetahi tangata e takoto ana te tangata kua mate ki MERS mohiotia i haere mai ki te kua ki te whakapā ki te kamera ranei tata inu waiu kamera. [30] I te 9 o Ākuhata 2013, he pūrongo i roto i te hautaka whakakitea te Diseases Lancet hopuhopu e i he paturopi pūmua-motuhake 50 i roto i te 50 (100%) te toto serum i nga kamera Omani me te 15 o te 105 (14%) i te kamera Spanish ki te MERS-ngaahi Te titi pūmua. Toto serum i te hipi te Pākehā, koati, kararehe, me era atu camelids i kahore he paturopi taua. [31] Whenua rite Hauti Arapia, me te United Arab Emirates hua a pau nui o te kai kamera. Ko te pea te vai e pekapeka African Ahitereiria ranei te whanga i te huaketo, me te tuku i te reira ki nga kamera. Kamera kawemai i enei rohe kua kawea ai te huaketo ki te Middle Te Tai Rāwhiti. [32] I te 2013 i kitea MERS-ngaahi i roto i ngā mema e toru o te kau kamera kamera i tū i roto i te whare witi Qatar, i honoa ki te rua ngā take tangata whakapumautia nei mai i whakahokia. Ko te aroaro o MERS-ngaahi i roto i te kamera whakaūngia e te National Institute of Health Public me Environment (RIVM) o te Tāhuhu o te Hauora me te Erasmus Medical Center (WHO i mahi Center), te Hōrana. E kore tetahi o nga kamera whakakitea tetahi tohu o te mate, ka kohia te tauira i. Ko te Supreme Kaunihera o Health Qatar tohutohu i roto i te Noema o 2013 e te iwi ki te tikanga hauora e whāriki ana, pērā i te mate ngakau, mate huka, mate tākihi, mate romahā, te immunosuppressed, me te kaumātua, te karo i tetahi whakapā kararehe tata i te haere ki ngā pāmu, me te hokohoko, a ka ki te mahi akuaku pai, pērā i te horoi ringa. [33] He ako atu i runga i nga kamera kamera i Hauti Arapia whakaputaina i roto i te Hakihea 2013 whakakitea te aroaro o MERS-ngaahi i te 90% o nga kamera kamera arotakea (310), kï ana kamera kamera e kore anake i taea e te awa ki matua o MERS-ngaahi, engari ano te puna kararehe o MERS. [34] E ai ki te whakahou whakarāpopototanga MERS-ngaahi 27 March 2014, tautoko rangahau tata e mahi kamera rite te puna tuatahi o te tangata te whakaparu i MERS-ngaahi, i kia pekapeka te awa ki hopea o te huaketo. Taunakitanga ngā te auau ki te e kua kitea te huaketo i roto i nga kamera ki te e kua kitea take tangata, raraunga seriological e whakaatu ana te tuku whānui i roto i nga kamera, me te ōrite o te kamera ngaahi ki te ngaahi tangata. [35] Taxonomy [edit] Te whanaunga tata atu MERS-ngaahi ki te coronaviruses pekapeka HKU4 me HKU5 (te kawei 2c) atu i te mea ki te mahaha-ngaahi (kāwai 2B) (2, 9), te faaiteraa i te tuakiri raupapa neke atu i te 90% ki o ratou hononga tata, pekapeka coronaviruses HKU4 me te HKU5 a reira ki te whakaaro riro ki te taua momo i te Komiti i runga i International Taxonomy o wheori (ICTV).

    Mnemonic:
    Pūtāutu taxon:
    Ingoa Scientific: Middle coronavirus syndrome romahā Te Tai Rāwhiti [1]
    Ingoa Common: MERS-ngaahi
    Kupu Taurite: Taumaha whakapeka coronavirus syndrome romahā
    Ētahi atu ingoa:
        coronavirus pūrākau (nCoV)
        Pūrākau London1 ngaahi 2012 [36]
        Human Coronavirus Erasmus Medical Center/2012 (HCoV-EMC/2012)
    Rangatira:
    Te whakapapa:

    > Huaketo

        > Wheori ssRNA

            > Group: IV; -tikanga pai, kotahi-paea wheori riihitia ana

                > Order: Nidovirales

                    > Family: Coronaviridae

                        > Iti: Coronavirinae

                            > Puninga: Betacoronavirus [37]

                                > Momo: Betacoronavirus 1 (nuitia i huaina coronavirus Human OC43), Human coronavirus HKU1, coronavirus Murine, Pipistrellus pekapeka coronavirus HKU5, Rousettus pekapeka coronavirus HKU9, Taumaha pauku coronavirus e pā ana-syndrome romahā, Tylonycteris pekapeka coronavirus HKU4, MERS-ngaahi

    Mano huaketo:
        Iwitanga Aitanga a (tangata)
        Bats [24] [25] [28] [37] [38]
        Poaka [37]
Auê:

    Tutakina:
    Tutakina:
    NCBI
Microbiolog Tupu noa i te huaketo i te Vero ngā pūtau me LLC-MK2 ngā pūtau. [9] Tautohetohe Rangahau / IP Kihai i rangatira Hauti hoatu whakaaetanga ki a Dr Zaki ki te tukua atu he tauira o te huaketo ki Fouchier me i riri ratou no te kokoraho Fouchier te ārai i runga i te raupapa tonu iranga [39] o te coronavirus syndrome romahā Middle Te Tai Rāwhiti. [39] I pupuhi te ētita o te Economist kite, "āwangawanga mo te haumarutanga kore me āta akiaki mahi. Tuatapaparaa i te huaketo whakamate he meá. Ehara i ako he riskier." [39] Dr Zaki i tona mahi i te hōhipera rite ki te hua o te tiri tona tauira me ngā kitenga. [40] [41] [42] [43] I to ratou hui ā-tau o te Assembly Health World i Mei 2013, ka korerotia rangatira WHO Margaret Chan e mana whakairo hinengaro, Patents i runga i ngā taumahatanga o te huaketo hou ranei, e kore e arai atu nga iwi i tiaki i to ratou tangata e whāiti hōparatanga pūtaiao. Whakaarahia Tuarua Minita Hauora Ziad Memish āwangawanga e kore e nga kaiputaiao nei i puritia te ārai hoki i te huaketo MERS-ngaahi tuku atu nga kaiputaiao ki te whakamahi i ngā rauemi me te arai i reira roa te te whanaketanga o te whakamātau tātaritanga. Pahono [44] Erasmus MC e kore i te tono ārai te aukati i rangahau hauora tūmatanui ki MERS coronavirus, [45] ka e te huaketo me te whakamātau tātaritanga etahi i tukuna-utu o te tiaki-ki katoa i tono taua tauhohenga.