TIMI BERKHASIAT SIRNAKAN BATUK
Pada
pengobatan secara konvensional, umumnya obat batuk mengandung senyawa
kimia antitusif, dekongestan, ekspektorat atau campuran keduanya.
Sebagai alternatif untuk pengobatan penyakit batuk dapat dilakukan
dengan menggunakan tanaman timi (Thyimus vulgaris L). Fungsi
utama timi sebagai obat batuk adalah karena adanya senyawa aktif yang
terkandung di dalamnya seperti tymol dan carvarol yang bermanfaat
sebagai ekspektoran dan anti pasmodik.
Minyak timi dapat dihasilkan dengan cara
menyuling tanaman timi yang terdiri dari tangkai dan daun dengan cara
penyuling uap dan air. Rendemen minyak yang dihasilkan berkisar
antara1,86-1,97% (M. Januwati, 2012).
Herba timi dapat diolah menjadi ekstrak
yaitu dengan mengekstrak simplisia timi yang sudah diolah menjadi
serbuk. Ektraksi timi dapat dilakukan dengan menggunakan pelarut etanol
70% dan hasilnya adalah berupa ekstrak kental.
KOMPOSISI KIMIA TIMI
Senyawa aktif yang terdapat pada minyak
timi merupakan senyawa phenol dengan komponen utamanya terdiri dari
thymol sebesar 30-70% dan carvacrol 70%. Selain itu di dalam minyak
timi juga terdapat senyawa thymol methyl eter 1,5-2,5%, p-cymene,
terpinene, linalool, dan juga mengandung senyawa golongan flavonoid
yaitu Circineol, 8-methoxycircineol, thymonin dan eriodyctol. Menurut
(Joanneet al, 2007; Anonim, 2008) senyawa biphenyl: asam-asam phenolat, termasuk asam rosmarinat.
Tymol Carvacol
MANFAAT MINYAK DAN EKSTRAK TIMI
Minyak
timi berfungsi sebagai pengencer dahak (sekretolitik), aktivitas ini
berkaitan dengan senyawa saponin pada ekstrak (KEMKES., 2011), dan
ekstrak timi dilaporkan dapat meningkatkan sekresi mucus (membantu
mengeluarkan dahak dari bronchi) (WHO, 1999). Selain itu minyak timi
juga berkhasiat menurunkan tekanan darah dan merangsang sistem
pernafasan serta meningkatkan kontraksi ritme jantung pada kelinci
percobaan. Kandungan thymol dan carvacrol dari herba timi, bisa sebagai
antitusif yang (menyebabkan ngantuk). Minyak atsiri timi menghambat
produksi sintesa asam rosmarinatnya yang mempunyai efek anti-inflamsi
(anti peradangan), dan thymol dan minyak atsiri juga memiliki efek
sebagai antelmintik (membasmi cacing), anti-bakteri dan anti-jamur
prostalglandin (KEMKES., 2011).
Penelitian secara in vitro menunjukkan senyawa aktif thymol memiliki aktivitas sebagai anti-fungi terhadap Cryptococcus neoformans, Aspergillus, Saprolegnia, dan Zygorhynch dan sebagai anti-bakteri terhadap spesies-spesies: Salmonella typhimurium, Staphylococcus aureus, Escherichia coli. Sebagai
agen anti-biotik, thymol 25 kali lebih efektif dibandingkan fenol dan
relatif lebih aman dibandingkan fenol (WHO, 1999). Minyak atsiri dari
timi tidak memiliki aktivitas mutagenik terhadap Bacillus subtilis ataupun terhadap Salmonella. Luteolin yang terkandung dalam timi merupakan anti-mutagen yang kuat terhadap senyawa karsinogen Trp-P-2 (Musa et al.,
2004). Selanjutnya, dari uji klinik secara acak terhadap 60 pasien
yang menderita batuk produktif selama 5 hari pengujian, menunjukkan
bahwa sirup timi memiliki efek yang setara dengan bromhexin (Joanneet al., 2007).
Tanaman timi merupakan tanaman
multifungsi selain sebagai obat batuk juga bermanfaat sebagai anti
bakteri, anti jamur, anti inflamasi, antelmintik dan aromaterapi.
Bentuk produk dari herba timi dapat berupa minyak atsiri, ekstrak dan simplisia. Metabolit sekunder utama dari herba timi adalah timol dan karvakrol.(Bagem Sembiring/Peneliti Pascapanen Balittro).
Efficacious TIMI SIRNAKAN COUGH
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Category : Latest News
Published on Wednesday , 31 July 2013 02:03
Written by Super UserIn conventional medicine , cough syrups generally contain chemical compounds antitussives , decongestants , ekspektorat or a mixture of both . As an alternative for the treatment of cough can be done using thyme plants ( Thyimus vulgaris L ) . The main function of thyme as a cough is due to an active compound contained in such tymol and carvarol useful as an expectorant and anti pasmodik .Thyme oil can be produced by means of distilling plants consisting of thyme stalks and leaves by means of steam and water distillers . The yield of oil produced antara1 ranging from 0.86 to 1 , 97 % ( M. Januwati , 2012) .Thyme herb extracts that can be processed to extract the crude drug with thyme that has been processed into powder . Thyme extraction can be performed using 70 % ethanol, and the result is a viscous extract .CHEMICAL COMPOSITION TIMIThe active compounds found in thyme oil is the main component of phenol compounds composed of 30-70 % thymol and carvacrol at 70 % . In addition there is also a compound of thyme oil thymol methyl ether 1.5-2.5 % , p - cymene , terpinene , linalool , and also contain flavonoid compounds that Circineol , 8 - methoxycircineol , thymonin and eriodyctol . According to ( Joanneet al , 2007; Anonymous , 2008) biphenyl compounds : phenolat acids , including rosmarinat acid .
Tymol CarvacolBENEFITS OF OIL AND EXTRACT TIMI[ Oil thyme ] thyme oil serves as a diluent sputum ( secretolytic ) , this activity relates to compounds of saponins in the extract ( KEMKES. , 2011 ) , and thyme extract has been reported to increase the secretion of mucus ( helps remove phlegm from the bronchi ) ( WHO , 1999 ) . In addition it is also efficacious thyme oil lowers blood pressure and stimulates the respiratory system as well as improve heart rhythm contraction in guinea pigs . The content of thymol and carvacrol from thyme herb , which can be as antitussives ( causes drowsiness ) . Thyme essential oil inhibits the production of acid synthesis rosmarinatnya which have anti - inflammatory effects ( anti- inflammatory ) , and thymol and essential oils also have effect as anthelmintic ( eradicate worms ) , anti - bacterial and anti - fungal prostaglandins ( KEMKES. , 2011) .
In vitro studies demonstrated the active compounds thymol have anti - fungal activity against Cryptococcus neoformans , Aspergillus , Saprolegnia , and Zygorhynch and as an anti - bacterial against species : Salmonella typhimurium , Staphylococcus aureus , Escherichia coli . As an anti - biotic agent , thymol 25 times more effective than phenol and relatively safer than phenol ( WHO , 1999) . Essential oils of thyme has no mutagenic activity against Bacillus subtilis or against Salmonella . Luteolin contained in thyme is a strong anti - mutagenic carcinogens compounds against Trp - P - 2 ( Moses et al . , 2004) . Furthermore , from a randomized clinical trial of 60 patients suffering from productive cough for 5 days of testing , showed that thyme syrup having equivalent effect bromhexin ( Joanneet al . , 2007 ) .Plant thyme plant is a multifunctional addition to the cough medicine is also useful as an anti- bacterial , anti- fungal , anti- inflammatory , anthelmintic and aromatherapy . Product form of the herb thyme may include essential oils, extracts and botanicals . The main secondary metabolites of the herb thyme is thymol and carvacrol . ( Bagem Sembiring / Postharvest Research IMACRI ) .
Category : Latest News
Published on Wednesday , 31 July 2013 02:03
Written by Super UserIn conventional medicine , cough syrups generally contain chemical compounds antitussives , decongestants , ekspektorat or a mixture of both . As an alternative for the treatment of cough can be done using thyme plants ( Thyimus vulgaris L ) . The main function of thyme as a cough is due to an active compound contained in such tymol and carvarol useful as an expectorant and anti pasmodik .Thyme oil can be produced by means of distilling plants consisting of thyme stalks and leaves by means of steam and water distillers . The yield of oil produced antara1 ranging from 0.86 to 1 , 97 % ( M. Januwati , 2012) .Thyme herb extracts that can be processed to extract the crude drug with thyme that has been processed into powder . Thyme extraction can be performed using 70 % ethanol, and the result is a viscous extract .CHEMICAL COMPOSITION TIMIThe active compounds found in thyme oil is the main component of phenol compounds composed of 30-70 % thymol and carvacrol at 70 % . In addition there is also a compound of thyme oil thymol methyl ether 1.5-2.5 % , p - cymene , terpinene , linalool , and also contain flavonoid compounds that Circineol , 8 - methoxycircineol , thymonin and eriodyctol . According to ( Joanneet al , 2007; Anonymous , 2008) biphenyl compounds : phenolat acids , including rosmarinat acid .
Tymol CarvacolBENEFITS OF OIL AND EXTRACT TIMI[ Oil thyme ] thyme oil serves as a diluent sputum ( secretolytic ) , this activity relates to compounds of saponins in the extract ( KEMKES. , 2011 ) , and thyme extract has been reported to increase the secretion of mucus ( helps remove phlegm from the bronchi ) ( WHO , 1999 ) . In addition it is also efficacious thyme oil lowers blood pressure and stimulates the respiratory system as well as improve heart rhythm contraction in guinea pigs . The content of thymol and carvacrol from thyme herb , which can be as antitussives ( causes drowsiness ) . Thyme essential oil inhibits the production of acid synthesis rosmarinatnya which have anti - inflammatory effects ( anti- inflammatory ) , and thymol and essential oils also have effect as anthelmintic ( eradicate worms ) , anti - bacterial and anti - fungal prostaglandins ( KEMKES. , 2011) .
In vitro studies demonstrated the active compounds thymol have anti - fungal activity against Cryptococcus neoformans , Aspergillus , Saprolegnia , and Zygorhynch and as an anti - bacterial against species : Salmonella typhimurium , Staphylococcus aureus , Escherichia coli . As an anti - biotic agent , thymol 25 times more effective than phenol and relatively safer than phenol ( WHO , 1999) . Essential oils of thyme has no mutagenic activity against Bacillus subtilis or against Salmonella . Luteolin contained in thyme is a strong anti - mutagenic carcinogens compounds against Trp - P - 2 ( Moses et al . , 2004) . Furthermore , from a randomized clinical trial of 60 patients suffering from productive cough for 5 days of testing , showed that thyme syrup having equivalent effect bromhexin ( Joanneet al . , 2007 ) .Plant thyme plant is a multifunctional addition to the cough medicine is also useful as an anti- bacterial , anti- fungal , anti- inflammatory , anthelmintic and aromatherapy . Product form of the herb thyme may include essential oils, extracts and botanicals . The main secondary metabolites of the herb thyme is thymol and carvacrol . ( Bagem Sembiring / Postharvest Research IMACRI ) .
